Efficacy and Safety of Hybrid Cardiac Telerehabilitation in Patients with Hypertrophic Cardiomyopathy without Left Ventricular Outflow Tract Obstruction and Preserved Ejection Fraction—A Study Design

Hypertrophic cardiomyopathy (HCM) is the most common congenital disease increasing risk of sudden cardiac death. For many years, HCM patients were excluded from exercise training. However, there are data showing that with undergoing supervised training could improve physical performance without serious adverse events. A project was designed as a randomized clinical trial to assess effectiveness and safety hybrid rehabilitation (HCR)—a combination hospital-based (1 month) new form home-based telemonitored (2 months) in left ventricular (LV) outflow tract obstruction preserved systolic function. Sixty who fulfil inclusion criteria have been randomly assigned (1:1) either HCR plus usual care (training group) or only (control group). The primary endpoint functional capacity evaluated by peak oxygen uptake (pVO2). Secondary endpoints include workload time during cardiopulmonary testing, six-minute walk test distance, NT-pro BNP level, echocardiographic parameters diastolic function (E/A, E/e’, myocardial strain rate), right pressure, gradient LV tract, quality life. tertiary analysis includes safety, acceptance adherence program. Our research will provide innovative on Clinical trials registry: ClinicalTrials.gov Identifier NCT03178357.